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Related Experiment Video

Updated: Jul 10, 2025

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
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Exploring functional connectivity alterations in sudden sensorineural hearing loss: A multilevel analysis.

Jing Li1, Yan Zou1, Xiangchuang Kong1

  • 1Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China.

Brain Research
|November 18, 2023
PubMed
Summary

Sudden sensorineural hearing loss (SSNHL) alters brain connectivity, affecting auditory and attention networks. These changes correlate with hearing loss duration and tinnitus severity, offering insights into SSNHL

Keywords:
Functional connectivity alterationsFunctional reorganizationInterNetworkIntraNetworkResting-state functional magnetic resonance imagingUnilateral sudden sensorineural hearing loss

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Area of Science:

  • Neuroscience
  • Audiology
  • Medical Imaging

Background:

  • Sudden sensorineural hearing loss (SSNHL) is an otologic emergency with known brain region alterations.
  • Previous research indicates changes in both auditory and non-auditory brain areas in SSNHL patients.
  • Understanding functional connectivity changes is crucial for comprehending SSNHL's neural impact.

Purpose of the Study:

  • To investigate functional connectivity alterations in sudden sensorineural hearing loss (SSNHL) patients.
  • To examine changes at integrity, network, and edge levels of brain connectivity.
  • To correlate connectivity changes with SSNHL duration and tinnitus severity.

Main Methods:

  • Functional connectivity analysis was performed on 107 SSNHL patients and 77 healthy controls.
  • Investigated overall functional connectivity degree across 55 nodes in nine brain networks.
  • Assessed intranetwork and internetwork connectivity strength, applying false discovery rate and Bonferroni corrections.

Main Results:

  • SSNHL patients exhibited altered functional connectivity at integrity, network, and edge levels.
  • Reduced intranetwork connectivity was found in sensory and attention networks (somatomotor, auditory, ventral/dorsal attention).
  • Increased internetwork connectivity was observed, particularly involving dorsal attention, frontoparietal, default mode, and limbic networks.

Conclusions:

  • SSNHL significantly impacts brain functional connectivity across multiple networks.
  • Connectivity alterations correlate with SSNHL duration and tinnitus burden, suggesting neural adaptation and dysfunction.
  • Findings provide insights into SSNHL's neural mechanisms, aiding future diagnostic and therapeutic strategies.