Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

TGF - β Signaling Pathway

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...

Brain Imaging

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

PET imaging of atherosclerotic plaques using the stabilin-2-targeted tracer <sup>18</sup>F-S2P in preclinical models.

European journal of nuclear medicine and molecular imaging·2026

Same author

Partial Amorphization of Proton-Conducting Perovskites Triggers Interfacial Water Optimization to Boost Proton Transfer Kinetics for PEM Electrolysis.

Small (Weinheim an der Bergstrasse, Germany)·2026

Same author

When technology awakens willingness but stalls action: the asymmetric psychological translation of managerial safety cognition.

Frontiers in psychology·2026

Same author

LysePred: A Multiscale Convolutional Neural Network for Predicting Hemolytic Activity of Antimicrobial Peptides.

ACS synthetic biology·2026

Same author

EGCG inactivates tumor necrosis factor-alpha (TNFα) by inducing its higher-order assembly.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2026

Same author

FcRL4 is an IgA receptor that primarily binds the joining chain.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same journal

Global Research Trends and Mechanistic Insights of Sirtuins in Alzheimer's Disease: A Bibliometric and Translational Review.

Brain research bulletin·2026

Same journal

N6-methyladenosine Demethylase ALKBH5 Mediates Remote Ischemic Postconditioning in Cerebral Ischemia-Reperfusion Injury by Regulating KLF4.

Brain research bulletin·2026

Same journal

Expression of concern: "Effect of perioperative preemptive analgesia on hippocampal GABAA receptor α1/α5 balance in aged mild cognitive impairment rats" [Brain Res. Bull. 237 (2026) 111811].

Brain research bulletin·2026

Same journal

Ubiquitination in ischemic stroke: Molecular mechanisms and therapeutic implications.

Brain research bulletin·2026

Same journal

Corrigendum to "Peripheral to central: Exploring the neural, endocrine, and immune pathways of the gut-brain axis in postoperative neurocognitive dysfunction" [Brain Res. Bull. 242 (2026) 111975].

Brain research bulletin·2026

Same journal

GLUT1-driven glycolytic reprogramming in microglia promotes neuroinflammation and cognitive deficits in sepsis-associated encephalopathy.

Brain research bulletin·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 10, 2025

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

Published on: October 27, 2020

The relationship between TGF-β1 and cognitive function in the brain.

Chen Su¹, Jie Miao¹, Junhong Guo¹

¹Department of Neurology, First Hospital of Shanxi Medical University, Taiyuan, Shanxi Province 030000, China.

Brain Research Bulletin

|November 18, 2023

Summary

This summary is machine-generated.

Transforming growth factor-β1 (TGF-β1) impacts cognitive function and neurodegenerative diseases. More research is needed to understand TGF-β1

Keywords:

Cognition Neurological diseases Neurovascular unit Synapses TGF-β1

More Related Videos

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Published on: January 19, 2022

A Pilot Study on the Repetitive Transcranial Magnetic Stimulation of Aβ and Tau Levels in Rhesus Monkey Cerebrospinal Fluid

A Pilot Study on the Repetitive Transcranial Magnetic Stimulation of Aβ and Tau Levels in Rhesus Monkey Cerebrospinal Fluid

Published on: September 3, 2021

Related Experiment Videos

Last Updated: Jul 10, 2025

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

Published on: October 27, 2020

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Published on: January 19, 2022

A Pilot Study on the Repetitive Transcranial Magnetic Stimulation of Aβ and Tau Levels in Rhesus Monkey Cerebrospinal Fluid

A Pilot Study on the Repetitive Transcranial Magnetic Stimulation of Aβ and Tau Levels in Rhesus Monkey Cerebrospinal Fluid

Published on: September 3, 2021

Area of Science:

Neuroscience
Molecular Biology
Cell Biology

Background:

Transforming growth factor-β1 (TGF-β1) is a key cytokine.
It regulates synaptic plasticity and neurovascular units.
Its role in cognitive function is increasingly recognized.

Purpose of the Study:

To review the multifaceted role of TGF-β1 in cognitive function.
To explore its implications in neurodegenerative disorders.
To identify gaps in current understanding and future research directions.

Main Methods:

Literature review of studies on TGF-β1 and cognition.
Analysis of TGF-β1's involvement in synaptic and neurovascular processes.
Synthesis of evidence linking TGF-β1 to neurodegeneration.

Main Results:

TGF-β1 influences synaptic formation and plasticity.
It plays a role in regulating the neurovascular unit.
Evidence suggests a connection between TGF-β1 dysregulation and cognitive decline in neurodegenerative diseases.

Conclusions:

TGF-β1 is a critical factor in cognitive function.
Its precise mechanisms in neurodegeneration require further elucidation.
Targeting TGF-β1 may offer therapeutic potential for cognitive disorders.