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Objectively measured cognitive dysfunction in patients with primary hyperparathyroidism improves after

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  • 1Michael E. DeBakey Department of Endocrine Surgery, Baylor College of Medicine, Houston, TX.

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Primary hyperparathyroidism (PHPT) is linked to cognitive dysfunction. Parathyroidectomy surgery significantly improved cognitive function in patients with PHPT, with improvements seen as early as two weeks post-operation.

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Area of Science:

  • Endocrinology
  • Neurosurgery
  • Cognitive Science

Background:

  • Primary hyperparathyroidism (PHPT) is associated with reduced quality of life, often measured by patient-reported outcomes.
  • Objective data demonstrating cognitive dysfunction in PHPT patients is limited.
  • This study investigates the impact of parathyroidectomy on objectively measured cognitive function.

Purpose of the Study:

  • To assess whether parathyroidectomy leads to quantifiable cognitive improvement in patients with PHPT.
  • To evaluate the association between parathyroidectomy and neurocognitive changes using objective measures.
  • To identify specific cognitive domains affected by PHPT and improved by surgery.

Main Methods:

  • 59 consecutive PHPT patients undergoing parathyroidectomy were assessed.
  • BrainCheck, a validated neurocognitive tool, was used for pre- and postoperative assessments.
  • Statistical analysis, including the Wilcoxon signed-rank test, evaluated cognitive changes.

Main Results:

  • 44.1% of patients exhibited preoperative neurocognitive dysfunction, decreasing to 22% postoperatively.
  • A significant overall improvement in cognitive scores was observed after parathyroidectomy (P = .004).
  • Improvements in executive function were significantly associated with parathyroidectomy (P < .01).

Conclusions:

  • PHPT is associated with objectively measurable cognitive changes.
  • Parathyroidectomy can reverse these cognitive deficits, with improvements noted as early as 2 weeks post-surgery.
  • Further research with larger cohorts is recommended to confirm these findings.