[Research progress of dendritic cell-associated C-type lectin-1 (dectin-1) in anti-tumor immunology]

Dendritic cell-associated C-type lectin 1 (dectin-1) receptor is the main pattern recognition receptor for β-glucan on the fungal cell wall. Dectin-1 is extensively expressed in myeloid cells including dendritic cells (DCs), macrophages, and neutrophils. After binding with endogenous and exogenous ligands, dectin-1 can induce intracellular signal transduction and trigger a series of cellular immune responses, and participate in anti-infection and anti-tumor processes. The interaction between dectin-1 and its different ligands triggers different signal activation pathways and cell functions. The recognition of dectin-1 with β-glucan promotes the maturation of DCs and its ability to present antigen to T cells, which induces the proliferation of cytotoxic T lymphocytes, and activates the specific immune response in vivo, thus playing an anti-tumor role. The article summarizes the structure and signaling pathway of the dectin-1 molecule and its research progress in anti-tumor immunity.