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Architecturally designed sequential-release hydrogels.

Dan Zhang1, Zimu Li2, Li Yang1

  • 1School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, 518107, China.

Biomaterials
|November 19, 2023
PubMed
Summary
This summary is machine-generated.

Sequential drug delivery hydrogels (SDDHs) offer a promising solution for multi-stage drug release, mimicking natural body processes. This review explores SDDH design using architectural principles to advance molecular pharmaceutics.

Keywords:
Architectural designDisease treatmentHydrogelsMechanismsSequential drug delivery

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Area of Science:

  • Molecular Pharmaceutics
  • Biomaterials Science
  • Drug Delivery Systems

Background:

  • Drug synergy has advanced clinical applications, but single administration, multi-stage release remains a challenge.
  • Hydrogels are versatile drug delivery systems due to their biocompatibility and modifiability.
  • Sequential Drug Delivery Hydrogels (SDDHs) combine hydrogel benefits with sequential release capabilities.

Purpose of the Study:

  • To provide insights into recent developments in SDDHs.
  • To connect SDDH construction factors (mechanisms, carrier structure, stimuli-responsiveness) with architectural design principles.
  • To elucidate dual-drug collocation, hydrogel preparation technologies, and current challenges.

Main Methods:

  • Review of architectural design principles applied to SDDH construction.
  • Analysis of mechanisms, carrier spatial structure, and stimuli-responsiveness in SDDHs.
  • Discussion of dual-drug collocation and advanced hydrogel preparation techniques.

Main Results:

  • Established parallels between SDDH design elements and architectural concepts (materials, structure, interactive furniture).
  • Highlighted the potential of SDDHs to emulate natural physiological processes for controlled drug release.
  • Identified key factors influencing SDDH performance and future research directions.

Conclusions:

  • SDDHs represent a significant advancement in achieving "single administration, multi-stage release."
  • Architectural design provides a valuable framework for optimizing SDDH development.
  • Further research into dual-drug strategies and preparation technologies is crucial for clinical translation.