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Updated: Jul 10, 2025

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage
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DNA repair deficiency and the immune microenvironment: A pathways perspective

Yuzhen Zhou1, Kent W Mouw2

  • 1Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.

DNA Repair
|November 19, 2023
PubMed
Summary

DNA repair pathway alterations in tumors impact genomic stability and the tumor immune microenvironment. This dysfunction can enhance sensitivity to immune checkpoint inhibitors (ICIs) in solid tumors.

Keywords:
DNA repairGenome instabilityImmune systemImmunotherapy

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