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Updated: Jul 10, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
Advancing proteomics in nephrology: unraveling causal pathways and therapeutic targets
1Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA; Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.
Abstract:
Proteomics has illuminated disease pathophysiology, unearthed novel biomarkers, and bolstered risk assessment strategies. In nephrology, observational analyses unveil biomarkers associated with adverse outcomes, whereas genetics offer insights into causal pathways. Mendelian randomization offers the potential to link the two, uncovering causal relationships between biomarkers and kidney function. Lanktree et al. demonstrate Mendelian randomization's utility in identifying additional proteins affecting kidney function and kidney disease progression.
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