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Updated: Jul 10, 2025

Stereotactic Radiosurgery for Gynecologic Cancer

Stereotactic Radiosurgery for Gynecologic Cancer

Published on: April 17, 2012

Stereotactic Radiosurgery for Vestibular Schwannoma With Radiographic Brainstem Compression.

Alexandra N De Leo¹, Anjay Shah¹, Jonathan Li¹

¹Departments of Radiation Oncology.

American Journal of Clinical Oncology

|November 20, 2023

Summary

This summary is machine-generated.

Single-treatment stereotactic radiosurgery (SRS) for vestibular schwannoma (VS) with brainstem compression is safe and effective. This study shows 100% freedom from serious brainstem toxicity at 5 years for VS patients treated with linac SRS.

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Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

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Published on: May 8, 2018

Area of Science:

Neurosurgery
Radiation Oncology
Neurology

Background:

Vestibular schwannoma (VS) with brainstem compression poses treatment challenges.
The safety of single-treatment stereotactic radiosurgery (SRS) for VS with brainstem compression is debated.
Data on linear accelerator (linac)-based SRS for this condition are limited.

Purpose of the Study:

To report outcomes of linac-based SRS for VS with radiographic brainstem compression.
To evaluate the safety and efficacy of SRS in this patient population.

Main Methods:

139 patients with unilateral VS and brainstem compression treated with linac SRS (12.5 Gy single fraction).
Inclusion criteria required at least 1 year of MRI follow-up.
Primary endpoint: freedom from serious brainstem toxicity (≥grade 3 CTCAE v5). Secondary endpoint: freedom from tumor enlargement.

Main Results:

Median follow-up was 5 years.
At 5 years, 100% freedom from serious brainstem toxicity and 90% freedom from tumor enlargement.
Severe facial nerve damage occurred in 0.9% of patients without tumor enlargement.

Conclusions:

Linac-based SRS is a safe and effective treatment for VS with brainstem compression.
The study provides evidence supporting SRS for VS patients with brainstem compression but no motor deficits.