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Printable-Microencapsulated Ascorbic Acid for Personalized Topical Delivery.

Lapporn Vayachuta1, Meyphong Leang1, Jareerat Ruamcharoen2

  • 1National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), Khlong Luang, Pathum Thani 12120, Thailand.

ACS Applied Bio Materials
|November 20, 2023
PubMed
Summary
This summary is machine-generated.

Researchers developed printable microencapsulated ascorbic acid (AA) for personalized topical delivery using laser printing. This method offers a novel approach for targeted skincare applications with minimal cytotoxicity.

Keywords:
ascorbic acidlaser printerpersonalized topical deliveryprintable microencapsulationtransdermal delivery

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Area of Science:

  • Materials Science and Engineering
  • Pharmaceutical Sciences
  • Biotechnology

Background:

  • Ascorbic acid (AA) is a vital antioxidant with limited topical stability and skin penetration.
  • Personalized topical delivery systems are needed to enhance the efficacy of active ingredients like AA.
  • Laser printing technology offers potential for precise and customizable formulation of cosmetic and therapeutic agents.

Purpose of the Study:

  • To develop printable-microencapsulated ascorbic acid (AA) for personalized topical delivery.
  • To optimize the encapsulation and printing process for AA using rice flour and nanosilica.
  • To evaluate the topical delivery and skin permeation of encapsulated AA using an emulsion carrier system.

Main Methods:

  • Microencapsulation of AA in rice flour (10% AA content) with hydrophobic nanosilica treatment.
  • Fabrication of microencapsulated AA patterns using a commercial laser printer.
  • Formulation of an emulsion carrier system with pentylene glycol (P5G) or diethylene glycol monoethyl ether (DEGEE).
  • Assessment of topical absorption using Franz diffusion cells with Strat-M membranes.
  • Evaluation of cytotoxicity on fibroblast cells.

Main Results:

  • Successful fabrication of printable-microencapsulated AA with minor print defects.
  • Achieved an AA encapsulation of 0.28 mg/cm².
  • Demonstrated enhanced skin permeation with steady-state fluxes of 8.40 μg/h/cm² (P5G) and 10.04 μg/h/cm² (DEGEE).
  • Confirmed low cytotoxicity of the encapsulation products and carrier systems.

Conclusions:

  • Printable-microencapsulated AA can be successfully fabricated using laser printing technology.
  • The developed emulsion carrier systems effectively enhance AA permeation into the skin.
  • This technology holds promise for personalized topical delivery of ascorbic acid with good safety profiles.