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Updated: Jul 10, 2025
Measurement & Analysis of the Temporal Discrimination Threshold Applied to Cervical Dystonia
Published on: January 27, 2018
Therapeutic Benefit of Sensory Trick in Cervical Dystonia
Abhimanyu Mahajan1, David A Gonzalez1, Glenn T Stebbins1
1Rush Parkinson's Disease and Movement Disorders Program, Rush University Medical Center, Chicago, Illinois, USA.
Background:
Sensory tricks (STs) are voluntary maneuvers that dampen the abnormal movement in cervical dystonia (CD).
Objectives:
To investigate the effect of ST on CD severity and treatment.
Methods:
Data on 1039 individuals with a modified Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) score were extracted from the CD Patient Registry for Observation of OnabotulinumtoxinA (onabotA) Efficacy study. Univariate and multivariate models evaluated the direct and indirect impact of ST on CD severity and treatment, while controlling for confounds.
Results:
Complete ST was associated with a 10% lower mean onabotA dose. Absence of complete ST was associated with a higher onabotA dose after controlling for dystonia severity (OR = 1.37, P = 0.04). ST moderated the relationship between dystonia severity and toxin dose (β = -0.16, P = 0.02).
Conclusions:
ST is related to lower CD severity and toxin dose. It may have a direct effect on lowering toxin dose, independent of CD severity.
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