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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Outcomes of patients with higher-risk myelodysplastic syndromes/neoplasms treated with hypomethylating agents + venetoclax-an analysis from the International Consortium for MDS (icMDS) VALIDATE database.

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Related Experiment Video

Updated: Jul 10, 2025

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome
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Transfusion avoidance in myelodysplastic neoplasms.

Elizabeth A Griffiths1

  • 1Roswell Park Comprehensive Cancer Center, Elm & Carlton Sts, Buffalo, New York, USA.

Current Opinion in Hematology
|November 20, 2023
PubMed
Summary

Myelodysplastic neoplasms (MDS) cause anemia and transfusion dependence, impacting quality of life. Iron overload worsens this, but early treatment with new therapies can improve outcomes.

Area of Science:

  • Hematology
  • Oncology
  • Stem Cell Biology

Background:

  • Myelodysplastic neoplasms (MDS) are stem cell aging disorders causing ineffective hematopoiesis and risk of acute myeloid leukemia.
  • Anemia and transfusion dependence are significant complications in MDS, severely impacting quality of life and survival.
  • Managing anemia and its complications is crucial for patients with MDS, particularly those with low-risk disease.

Approach:

  • Reviewing recent scientific developments on iron overload in MDS.
  • Analyzing observational studies on iron overload in transfusion-dependent and non-transfusion-dependent MDS.
  • Evaluating the efficacy of established and newly approved therapies for MDS-related anemia.

Key Points:

  • Iron overload negatively affects red blood cell maturation and promotes the expansion of malignant clones in MDS.

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  • Iron overload is prevalent even in MDS patients not yet transfusion-dependent.
  • Early intervention with therapies for MDS-related anemia is more effective before significant transfusion dependence occurs.

    • Conclusions:

    • Iron overload is detrimental to hematopoiesis in MDS.
    • Understanding the role of transfusions and patient-reported outcomes is key for optimal MDS management.
    • Optimizing the application of recently developed therapies can enhance treatment response in MDS.