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Related Concept Videos

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Polymers are classified as linear or branched on the basis of their chain architecture. The polymer chains in linear polymers have a long chain-like structure with minimal to no branching at all. Even if a polymer features large substituent groups on the monomer, which appear as branches to the skeleton, it is not considered a branched polymer. A branched polymer contains secondary polymer chains that arise from the main polymer chain. The branching occurs when the polymer growth shifts from...
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Polymerization generates chiral centers along the entire backbone of a polymer chain. Accordingly, the stereochemistry of the substituent group has a significant effect on polymer properties. Polymers formed from monosubstituted alkene monomers feature chiral carbons at every alternate position in the polymer backbone. Relative to the predominant orientation of substituents at the adjacent chiral carbons, the polymer can exist in three different configurations: isotactic, syndiotactic, and...
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Unlike ionic or small covalent molecules, polymers do not form crystalline solids due to the diffusion limitations of their long-chain structures. However, polymers contain microscopic crystalline domains separated by amorphous domains.
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Robust and rapid partitioning in thermoplastic.

Phenix-Lan Quan1, Maria Alvarez-Amador1, Yuhe Jiang1

  • 1Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, 11794, USA. eric.brouzes@stonybrook.edu.

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|November 20, 2023
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Summary

This study presents a novel thermoplastic device for digital assays, enabling robust sample partitioning using capillary-driven liquid-air interface control. This innovation facilitates cost-effective, instrument-free platforms for molecular quantification, especially in low-resource settings.

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Area of Science:

  • Biotechnology
  • Materials Science
  • Microfluidics

Background:

  • Partitioning is crucial for digital assays, enabling molecular quantification.
  • Thermoplastics offer manufacturing advantages but pose challenges for microfluidic device fabrication.
  • Trapped air in nanoliter chambers hinders efficient priming in thermoplastic partitioning devices.

Purpose of the Study:

  • To design a thermoplastic partitioning array for digital assays.
  • To overcome challenges associated with air displacement in thermoplastic microfluidic devices.
  • To develop a cost-effective and instrument-free partitioning platform.

Main Methods:

  • Fabrication of a thermoplastic partitioning array.
  • Utilizing capillary effects to control liquid-air interface progression.
  • Testing device performance under varying pressures and low-pressure actuation.

Main Results:

  • Successful design and fabrication of a thermoplastic partitioning array.
  • Demonstrated robust partitioning across a range of pressures.
  • Achieved low-pressure actuation using a standard micropipette.

Conclusions:

  • The developed thermoplastic device enables efficient and controlled partitioning.
  • Capillary-driven interface control overcomes air-trapping issues in thermoplastic microfluidics.
  • This technology supports the development of affordable, instrument-free digital assay platforms for diverse settings.