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Updated: Jul 10, 2025

Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis

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Published on: November 8, 2024

Modeling Brain Gene Expression in Alcohol Use Disorder with Genetic Animal Models.

Robert Hitzemann¹, Angela R Ozburn², Denesa Lockwood²

¹Department of Behavioral Neuroscience, Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR, USA. hitzeman@ohsu.edu.

Current Topics in Behavioral Neurosciences

|November 20, 2023

Summary

This summary is machine-generated.

Animal models reveal key genetic factors in alcohol use disorder (AUD). Findings highlight synaptic transmission, extracellular matrix changes, and neuroimmune processes, aiding human genetic study interpretation.

Keywords:

Alcohol use disorder Animal genetic models Brain gene expression Drinking in the dark Ethanol preference GWAS RNA sequencing TWAS

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Published on: August 4, 2022

Area of Science:

Neuroscience
Genetics
Pharmacology

Background:

Animal genetic models are crucial for understanding alcohol use disorder (AUD) adaptations.
Existing research links AUD to complex genetic and neurobiological factors.
Interpreting human genetic data (GWAS, TWAS) requires robust animal models.

Purpose of the Study:

To evaluate the utility of ethanol preference and drinking in the dark (DID) models in AUD research.
To connect animal gene expression data with human AUD genetic studies.
To identify key biological pathways implicated in AUD using genetic models.

Main Methods:

Utilized established animal models: ethanol preference and drinking in the dark (DID).
Interrogated brain gene expression data from these animal models.
Correlated findings with human genome-wide association studies (GWAS) and transcriptome-wide association studies (TWAS) for AUD.

Main Results:

Animal and human data converge on the significance of altered synaptic transmission (glutamate, GABA).
Changes in the extracellular matrix, including collagens and cadherins, are critical for AUD.
Neuroimmune processes are strongly implicated in the genetic underpinnings of AUD.

Conclusions:

Genetic animal models, particularly ethanol preference and DID, are valuable for AUD research.
Findings underscore the roles of synaptic, extracellular matrix, and neuroimmune systems in AUD.
Emerging technologies like cell type-specific gene expression will enhance future animal model utility for AUD.