Related Experiment Video

Updated: Jul 10, 2025

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
07:44

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

Published on: November 28, 2019

7.5K

Metastasis suppressor genes and their role in the tumor microenvironment

Cristina Megino-Luque1, Jose Javier Bravo-Cordero2

  • 1Department of Medicine, Division of Hematology and Oncology, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Cancer Metastasis Reviews
|November 20, 2023
PubMed

Insights

Metastasis suppressor genes inhibit cancer spread. Recent research reveals their crucial role in regulating the tumor microenvironment, impacting cancer progression and treatment strategies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • The metastatic cascade is a complex, multi-step process crucial for cancer progression.
  • Metastasis suppressor genes are key regulators that inhibit the spread of cancer cells.
  • Emerging evidence highlights the involvement of these suppressor genes in modulating the tumor microenvironment.

Purpose of the Study:

  • To review recent advancements in understanding metastasis suppressor genes.
  • To explore the intricate relationship between metastasis suppressor genes and the tumor microenvironment.
  • To highlight the crosstalk between these genes and their surrounding cellular milieu.

Main Methods:

  • Literature review of recent studies on metastasis suppressor genes.
  • Analysis of research focusing on gene function within the tumor microenvironment.
  • Synthesis of findings on the interplay between metastasis suppressors and microenvironmental factors.

Main Results:

  • Metastasis suppressor genes are critical not only for inhibiting cell migration but also for influencing the tumor microenvironment.
  • These genes interact with various components of the microenvironment, including immune cells and extracellular matrix.
  • Dysregulation of metastasis suppressor genes can lead to a pro-metastatic microenvironment.

Conclusions:

  • Metastasis suppressor genes possess dual functions in controlling cancer metastasis and shaping the tumor microenvironment.
  • Targeting the crosstalk between metastasis suppressors and the microenvironment presents a promising therapeutic strategy.
  • Further research into these interactions is essential for developing effective anti-metastatic treatments.
Keywords:
CancerMetastasisMetastasis suppresor genesTumor microenvironment

More Related Videos

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis07:41

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

2.5K
A Proximal Culture Method to Study Paracrine Signaling Between Cells08:17

A Proximal Culture Method to Study Paracrine Signaling Between Cells

Published on: August 28, 2018

9.5K

Related Concept Videos

Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.4K
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
4.8K
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.6K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
21.3K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.5K