Recent Advances on NIR-II Light-Enhanced Chemodynamic Therapy

Area of Science:

• Biomedical Engineering
• Oncology
• Nanotechnology

Background:

• Chemodynamic therapy (CDT) generates toxic hydroxyl radicals (•OH) via Fenton reactions for cancer treatment.
• Single CDT efficacy is limited by unsatisfactory outcomes.
• Enhanced chemodynamic therapy (ECDT) uses light energy to improve CDT efficiency.

Purpose of the Study:

• To review mechanisms and strategies for improving near-infrared II (NIR-II) enhanced chemodynamic therapy (ECDT).
• To highlight the potential of NIR-II ECDT for deep tumor treatment and real-time imaging.
• To address limitations of visible and NIR-I light in amplified CDT.

Main Methods:

• Review of existing literature on NIR-II ECDT nanoplatforms.
• Analysis of strategies enhancing Fenton/Fenton-like reactions in ECDT.
• Discussion of NIR-II light properties (penetration, imaging, minimal damage).

Main Results:

• NIR-II light offers superior penetration and imaging capabilities compared to visible and NIR-I light.
• NIR-II ECDT nanoplatforms demonstrate improved deep tumor killing efficiency.
• NIR-II radiation (wavelengths >1000 nm) minimizes damage to normal tissues.

Conclusions:

• NIR-II enhanced chemodynamic therapy shows significant potential for clinical oncology.
• Strategies for optimizing NIR-II ECDT are crucial for overcoming current limitations.
• This review outlines key advancements and future directions in NIR-II ECDT.