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The potential clinical impact of cell type-specific genetic regulation: Crohn's disease
Rika Tyebally1,2, Angli Xue1,3, Joseph E Powell1,2
1Translational Genomics, Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales, Australia.
Abstract:
Complex diseases are heterogenous due to variation in their genetic and environmental underpinnings, leading to varied treatment responses. Genome-wide association studies (GWAS) integrated with single-cell expression quantitative trait loci analyses (eQTL) can pinpoint cell-type specific candidate disease-relevant genes and pathways. This knowledge can be applied to patient stratification and novel therapeutic target identification. Here, we describe the translational potential of cell-type specific genetic regulation, using Crohn's disease as an example.
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