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Comparing Copy Number Variations and SNPs02:26

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Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
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Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
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Humans engage in aggression when they seek to cause harm or pain to another person. Aggression takes two forms depending on one’s motives: hostile or instrumental. Hostile aggression is motivated by feelings of anger with intent to cause pain; a fight in a bar with a stranger is an example of hostile aggression. In contrast, instrumental aggression is motivated by achieving a goal and does not necessarily involve intent to cause pain (Berkowitz, 1993); a contract killer who murders for...
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Related Experiment Video

Updated: Jul 10, 2025

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
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Copy Number Variation Analysis of Aggressive Behaviour in Schizophrenia.

Vincenzo De Luca1,2, Zanib Chaudhary1, Nzaar Al-Chalabi1

  • 1CAMH, Toronto, Ontario, Canada.

Neuropsychobiology
|November 20, 2023
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Summary

Copy number variation (CNV) load did not correlate with violence in schizophrenia (SCZ). However, larger deletion events were significantly associated with violent behaviors in SCZ patients.

Keywords:
AggressionCopy number variationSchizophrenia

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Area of Science:

  • Genetics
  • Psychiatry
  • Neuroscience

Background:

  • Schizophrenia (SCZ) is linked to increased violence, though findings vary.
  • Comorbid substance use disorders and copy number variation (CNV) load may influence aggression in SCZ.

Purpose of the Study:

  • To investigate the correlation between CNV load and violence in individuals with schizophrenia spectrum disorders.
  • To explore the role of genetic factors, specifically CNV load, in aggressive behavior within a non-forensic SCZ population.

Main Methods:

  • Recruited 203 community-dwelling SCZ spectrum disorder patients from a non-forensic population.
  • Assessed aggression using a cross-sectional, retrospective design.
  • Conducted CNV analysis on genomic DNA using the Illumina Omni 2.5 array.

Main Results:

  • No significant correlation was found between the total number of CNV events (deletions or duplications) and the severity of physical violence.
  • A significant association was observed between larger deletion events and violent behaviors.

Conclusions:

  • The study suggests a potential link between specific types of CNV events (larger deletions) and violence in SCZ.
  • Further research with larger sample sizes and standardized aggression assessment tools is recommended to confirm these findings.