Cushing's syndrome

Area of Science:

• Endocrinology
• Internal Medicine
• Molecular Biology

Background:

• Endogenous Cushing's syndrome (CS) is characterized by excess endogenous glucocorticoid secretion.
• It leads to diverse clinical issues, comorbidities, and elevated mortality, even with treatment.
• Despite advances, diagnosis and management of CS remain complex.

Purpose of the Study:

• To provide an updated overview of endogenous Cushing's syndrome.
• To cover crucial aspects of diagnosis, associated complications, and current treatment strategies.
• To emphasize the importance of timely intervention for mitigating long-term health issues.

Main Methods:

• Review of recent literature on molecular mechanisms and genetic alterations in CS.
• Evaluation of advancements in diagnostic imaging and biochemical testing.
• Analysis of current surgical and medical therapeutic options.

Main Results:

• Significant progress in understanding molecular pathways and genetic underpinnings of CS.
• Enhanced diagnostic accuracy through improved imaging and biochemical assays.
• Development of novel medical therapies alongside established surgical approaches.

Conclusions:

• Accurate and prompt diagnosis of endogenous CS is critical.
• Effective management requires a multidisciplinary approach, integrating surgery and advanced medical therapies.
• Addressing persistent comorbidities is essential for improving long-term quality of life in patients with CS.