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Updated: Jul 31, 2026

Isolation and Derivation of Mouse Embryonic Germinal Cells
Published on: October 22, 2009
Effect of primidone in somatic and germ cells of mice
Abstract:
Primidone, an anti-convulsant drug, was tested in mice for mutagenicity in somatic cells by the micronucleus test and in germ cells by the sperm-head abnormality assay. Mice were treated orally with the drug at doses of 4.37, 8.75 and 13.11 mg/mouse. The results indicate that the drug is capable of inducing mutations both in somatic and germ cells of mice.
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