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Related Experiment Video

Updated: Jul 10, 2025

Methods for Detecting Cough and Airway Inflammation in Mice

Methods for Detecting Cough and Airway Inflammation in Mice

Published on: August 2, 2024

Illuminating Airway Nerve Structure and Function in Chronic Cough.

James Kornfield¹, Ubaldo De La Torre¹, Emily Mize¹

¹OHSU Division of Pulmonary, Allergy, and Critical Care Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Mail Code UHN67, Portland, OR, 97239, USA.

|November 20, 2023

Summary

Airway nerves control breathing and cough. Advances in imaging and genetic tools now allow detailed study of nerve changes in airway diseases like chronic cough.

Keywords:

Asthma Chronic cough Confocal microscopy Optogenetics Parasympathetic nerve Sensory nerve

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Area of Science:

Pulmonary Medicine
Neuroscience
Cell Biology

Background:

Airway nerves regulate essential functions like breathing and cough.
Dysregulation of these nerves contributes to airway diseases, including chronic cough.
Neural pathways in airway diseases can become sensitized, leading to exaggerated responses.

Purpose of the Study:

To review the heterogeneity of airway nerves in health and disease.
To highlight how recent methodological advancements aid in studying airway nerve morphology and function.
To discuss the role of neural remodeling in airway disease development.

Main Methods:

Utilizing confocal imaging to visualize neural organization.
Employing targeted genetic manipulation to study airway nerves.
Quantitatively assessing neural remodeling through advanced techniques.

Main Results:

Recent technological progress enables detailed visualization and modulation of airway nerves.
These advances provide unprecedented ability to study neuro-immune interactions.
Methodological improvements illuminate airway nerve morphology and function in disease states.

Conclusions:

Airway nerve heterogeneity is crucial in understanding airway function and disease.
Advanced imaging and genetic techniques offer new insights into neural remodeling.
These tools are vital for assessing the role of nerves in airway diseases like chronic cough.