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Pregnancy Outcomes in Patients with Early-Onset Idiopathic Chronic Pancreatitis

Gauri Kumbhar1, Sudipta Dhar Chowdhury2, Santosh Benjamin3

  • 1Department of Gastroenterology, Christian Medical College, Ranipet Campus, Vellore, Tamil Nadu, 632517, India.

Digestive Diseases and Sciences
|November 20, 2023
PubMed

Insights

Pregnancy outcomes for women with early-onset idiopathic chronic pancreatitis (EOICP) are similar to healthy women. This study found no significant differences in major pregnancy complications or fetal outcomes, suggesting EOICP does not negatively impact pregnancy.

Area of Science:

  • Gastroenterology
  • Obstetrics & Gynecology
  • Reproductive Medicine

Background:

  • Early-onset idiopathic chronic pancreatitis (EOICP) affects young individuals, but data on pregnancy outcomes are scarce.
  • Understanding pregnancy outcomes in EOICP is crucial for managing affected women.

Purpose of the Study:

  • To evaluate pregnancy outcomes in patients diagnosed with EOICP.
  • To determine the impact of pregnancy on the progression of EOICP.

Main Methods:

  • A cohort of 50 patients with EOICP, with disease onset before pregnancy, was studied.
  • Data collected included demographics, disease duration, pregnancy outcomes, and disease course.

Main Results:

  • 86 pregnancies were analyzed; 22.1% had unsuccessful outcomes, including spontaneous losses and stillbirths.
  • Rates of gestational diabetes, hypertension, preterm labor, and birth weight were comparable to general Indian populations.
  • Cesarean delivery rates (LSCS) were significantly higher (49.3%) compared to the Indian average (21.5%).
  • Pancreatic pain occurred in 42% of women, but did not affect maternal or fetal outcomes; no pancreatitis complications arose during pregnancy.

Conclusions:

  • Pregnancy outcomes for women with EOICP are comparable to those of healthy women in India.
  • Pregnancy does not appear to worsen the course of EOICP or lead to significant complications.
Abstract

Keywords:
Chronic pancreatitisFetal outcomesIdiopathic chronic pancreatitisMaternal outcomesPancreatitisPregnancy

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