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Related Concept Videos

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Articles linked to this work by shared authors, journal, and citation graph.

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Formulation development and optimization of sparfloxacin-loaded solid lipid nanoparticles integrated with microneedles for the treatment of biofilm-infected wounds.

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Updated: Jul 22, 2026

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
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AgNPs-Modified Polylactic Acid Microneedles: Preparation and In Vivo/In Vitro Antimicrobial Studies.

Wenqin Zhang1,2, Xiaozhen Cai2, Xinyi Zhang1,2

  • 1School of Pharmacy, Fujian Medical University, Fuzhou, 350122, China.

Pharmaceutical Research
|November 20, 2023
PubMed
Summary

Polylactic acid microneedles (PLAMNs) modified with silver nanoparticles (AgNPs) demonstrate sustained antibacterial effects. This innovation prevents skin infections, offering a safer alternative to traditional microneedle biosensors.

Keywords:
antibacterialdopaminepolydopaminepolylactic acid microneedlessilver nanoparticles

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Dermatology

Background:

  • Traditional microneedle (MN) biosensors risk causing skin infections.
  • Developing MNs with inherent antibacterial properties is crucial for safe biosensing applications.

Purpose of the Study:

  • To create polylactic acid microneedles (PLAMNs) with sustained antibacterial activity.
  • To prevent skin infections associated with MN-based biosensor usage.

Main Methods:

  • Synthesized silver nanoparticles (AgNPs) using polydopamine (PDA) via in-situ reduction.
  • Fabricated PLAMNs using a hot-melt method.
  • Modified PLAMNs with AgNPs via PDA in-situ reduction, creating PLAMNs@PDA-AgNPs.
  • Assessed physicochemical properties, in vitro/in vivo antibacterial efficacy, and biocompatibility.

Main Results:

  • PLAMNs@PDA-AgNPs exhibited excellent mechanical strength and a 100% puncture success rate.
  • SEM and EDS confirmed the successful surface modification with silver.
  • TEWL tests indicated rapid healing of micro-pores, demonstrating safety.
  • Both in vitro and in vivo studies confirmed significant antibacterial efficacy.

Conclusions:

  • PLAMNs@PDA-AgNPs provide sustained antibacterial activity, effectively addressing skin infection risks.
  • This technology presents a promising advancement for microneedle applications, enhancing safety and efficacy.
  • Offers a superior alternative to traditional MN-based biosensors for preventing infections.