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Related Concept Videos

Disorders of Leukocytes01:27

Disorders of Leukocytes

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Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
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Immunodeficiency Diseases01:25

Immunodeficiency Diseases

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
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Factors Affecting the Risk of Infection01:26

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
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Pulmonary Tuberculosis I01:29

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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
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Related Experiment Video

Updated: Jul 10, 2025

Isolation of CD4+ T-cells and Analysis of Circulating T-follicular Helper cTfh Cell Subsets from Peripheral Blood Using 6-color Flow Cytometry
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Early decrease in blood lymphocyte count is associated with poor prognosis in COVID-19 patients: a retrospective

Gong Chen1, Xiaofang Zhao2, Xinglin Chen3

  • 1Department of Anesthesiology, the Third Xiangya Hospital, Central South University, Changsha, China.

BMC Pulmonary Medicine
|November 21, 2023
PubMed
Summary
This summary is machine-generated.

Dynamic lymphocyte count changes in COVID-19 patients can predict mortality. A declining lymphocyte count in the early disease stage indicates a higher risk of death, while increasing counts suggest survival.

Keywords:
COVID-19Hospital mortalityLymphocyte count

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Area of Science:

  • Medical research
  • Immunology
  • Infectious diseases

Background:

  • Previous studies linked baseline lymphocyte count to COVID-19 mortality.
  • The prognostic value of dynamic lymphocyte changes during COVID-19 progression remained unclear.

Purpose of the Study:

  • To investigate the significance of lymphocyte count dynamics in predicting COVID-19 patient outcomes.
  • To analyze trends in lymphocyte counts over time in relation to survival status.

Main Methods:

  • Retrospective cohort study of 532 COVID-19 patients.
  • Generalized additive mixed model used to compare lymphocyte count trends between survivors and non-survivors.
  • Statistical analysis adjusted for potential confounders.

Main Results:

  • Lymphocyte counts declined in non-survivors and increased in survivors within 10 days of hospitalization.
  • A significant daily increase in lymphocyte count difference (0.0731 × 10^9/L) was observed between survivors and non-survivors after adjustment.
  • Overall in-hospital mortality was 5.45%.

Conclusions:

  • Dynamic changes in lymphocyte count during early COVID-19 reflect pathophysiological alterations.
  • An early decrease in lymphocyte count is a significant predictor of mortality in COVID-19 patients.