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Vascular endothelial growth factor-D plasma levels in fluid overload and cardiac function evaluation of elderly

Jun Li1,2, Xiao-Lin Li2, Fa-Hu Liu3

  • 1Department of Nephrology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China.

Medicine
|November 21, 2023
PubMed

Insights

Vascular Endothelial Growth Factor-D (VEGF-D) and Growth Differentiation Factor-15 (GDF-15) show promise as biomarkers for fluid overload and cardiac function in elderly cardiovascular patients. Higher VEGF-D levels correlate with heart failure severity and cardiac function indicators.

Area of Science:

  • Cardiology
  • Biomarker Discovery
  • Geriatric Medicine

Background:

  • Cardiovascular disease (CVD) in the elderly presents complex challenges in managing fluid overload and assessing cardiac function.
  • Existing biomarkers may not fully capture the intricate pathophysiology of CVD in older populations.

Purpose of the Study:

  • To investigate the clinical significance of vascular endothelial growth factor (VEGF) subtypes (VEGF-C, VEGF-D) and growth differentiation factor-15 (GDF-15) plasma levels.
  • To evaluate their utility in assessing fluid overload and cardiac function in elderly patients with CVD.

Main Methods:

  • Plasma levels of VEGF-C, VEGF-D, and GDF-15 were measured using ELISA in elderly CVD patients.
  • Correlations with N-terminal pro B-type natriuretic peptide (NT-pro BNP) and echocardiographic parameters were analyzed.

Main Results:

  • Higher plasma levels of VEGF-D and GDF-15 were observed in patients with CVD and heart failure.
  • VEGF-D levels positively correlated with NT-pro BNP and echocardiographic indicators of cardiac function and fluid overload.
  • GDF-15 levels correlated with biomarkers of cardiac and tubular injury, as well as age, kidney function, and nutritional status.

Conclusions:

  • VEGF-D shows potential as a biomarker for fluid overload and cardiac function in elderly CVD patients.
  • GDF-15 and NT-pro BNP levels are influenced by age, nutrition, and kidney function, impacting their use in assessing cardiac status.

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