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Related Experiment Video

Updated: Jul 10, 2025

Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq

Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq

Published on: March 12, 2021

Transcriptomics and chromatin accessibility in multiple African population samples.

Marianne K DeGorter¹, Page C Goddard², Emre Karakoc³

¹Department of Pathology, Stanford University, Stanford, CA.

Biorxiv : the Preprint Server for Biology

|November 21, 2023

Summary

This summary is machine-generated.

This study expands functional genomic data by analyzing African populations to discover novel transcripts and genetic variants influencing gene expression and chromatin accessibility, aiding disease research.

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Mapping Genome-wide Accessible Chromatin in Primary Human T Lymphocytes by ATAC-Seq

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Area of Science:

Genomics
Population Genetics
Molecular Biology

Background:

Functional genome mapping is limited by European-centric data.
Understanding genetic variant impact across diverse populations is crucial.

Conclusions:

This work enhances global functional genomic datasets, particularly for African ancestries.
Provides insights into the population genetic history of molecular quantitative trait loci.
Facilitates fine-mapping of GWAS signals for complex diseases and resolves genetic underpinnings of human traits.