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Altered hippocampal activation in seizure-prone CACNA2D2 knockout mice
Alyssa Danis1,2, Ashlynn A Gallagher1,2, Ashley N Anderson1,2
1Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, Portland, OR, 97239.
Biorxiv : the Preprint Server for Biology
|November 21, 2023
Summary
Mice lacking the voltage-gated calcium channel subunit α2δ-2 show decreased hippocampal activity after seizures. However, they exhibit increased susceptibility to proconvulsant stimuli without significant histopathological changes.
Area of Science:
- Neuroscience
- Epilepsy Research
- Calcium Channel Function
Background:
- Voltage-gated calcium channel subunit α2δ-2 (Cav2.1 α2δ-2) is crucial for neuronal calcium signaling.
- Loss of α2δ-2 is linked to epilepsy in mice and humans.
- Understanding hippocampal function in α2δ-2 deficient models is key to epilepsy research.
Conclusions:
- Absence of α2δ-2 alters seizure-associated hippocampal network function, leading to decreased activity post-convulsion.
- Mice lacking α2δ-2 display increased susceptibility to proconvulsant stimuli.
- Observed functional changes occur without typical temporal lobe epilepsy-associated structural alterations in the hippocampus.
