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Related Experiment Video

Updated: Jun 11, 2026

Real Time In Vivo Tracking of Thymocytes in the Anterior Chamber of the Eye by Laser Scanning Microscopy

Real Time In Vivo Tracking of Thymocytes in the Anterior Chamber of the Eye by Laser Scanning Microscopy

Published on: October 2, 2018

A spatial human thymus cell atlas mapped to a continuous tissue axis.

Nadav Yayon^1,2, Veronika R Kedlian¹, Lena Boehme³

¹Wellcome Sanger Institute, Cellular Genetics, Cambridge, United Kingdom.

Biorxiv : the Preprint Server for Biology

|November 21, 2023

Summary

T cell development pathways and thymic epithelial cells are highly organized by 12 weeks of gestation. This study maps the thymus

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Last Updated: Jun 11, 2026

Real Time In Vivo Tracking of Thymocytes in the Anterior Chamber of the Eye by Laser Scanning Microscopy

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Author Spotlight: Advancing Thymic Epithelial Cells and T-Cell Research with Human Thymic Organoids

Author Spotlight: Advancing Thymic Epithelial Cells and T-Cell Research with Human Thymic Organoids

Published on: October 4, 2024

Area of Science:

Immunology
Developmental Biology
Anatomy

Background:

T cell development is a complex process occurring in the thymus from fetal stages through adolescence.
Understanding the thymus' micro-anatomy is crucial for mapping T cell maturation and selection processes.
Pre- vs. post-natal differences in thymic structure and function remain incompletely understood.

Approach:

Developed a quantitative morphological framework, the Cortico-Medullary Axis, for analyzing thymic micro-anatomy.
Integrated spatial transcriptomics and multiplex imaging with single-cell data to create a multimodal atlas.
Performed spatially resolved analysis to map thymocyte trajectories and thymic epithelial cell organization.

Key Points:

Canonical thymocyte trajectories and thymic epithelial cells are fully established by post-conception week 12.
Identified specific thymic epithelial cell (TEC) progenitor states and linked TEC subsets to Hassall's Corpuscles.
Revealed distinct patterns in medullary entry for CD4 vs. CD8 T cell lineages.

Conclusions:

The thymus exhibits a highly organized structure early in development, established by 12 weeks of gestation.
The study provides a comprehensive spatial atlas and analytical toolkit for T lymphocyte development research.
Findings offer insights into the spatial and temporal regulation of T cell development in the thymus.