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Rodent Behavioral Testing to Assess Functional Deficits Caused by Microelectrode Implantation in the Rat Motor Cortex
Published on: August 18, 2018
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Neuronal functional connectivity is impaired in a layer dependent manner near the chronically implanted
Biorxiv : the Preprint Server for Biology
|November 21, 2023
Summary
Chronic brain implants disrupt neural circuit function, particularly in cortical layers 2/3 and hippocampal CA1 neurons, impacting Brain-Computer Interface (BCI) stability due to the foreign-body response (FBR).
Area of Science:
- Neuroscience
- Biomedical Engineering
- Neural Engineering
Background:
- Foreign-body response (FBR) to implanted devices causes signal degradation.
- Long-term effects of FBR on neural circuit stability near Brain-Computer Interfaces (BCIs) are not well understood.
- Understanding these effects is crucial for improving BCIs.
Conclusions:
- Characterized network connectivity dysfunction after long-term microelectrode implantation.
- Findings can inform therapeutic strategies for peri-implant tissue health.
- Results may guide the engineering of adaptive decoders for stable BCI performance.
