NeuroBooster Array: A Genome-Wide Genotyping Platform to Study Neurological Disorders Across Diverse Populations
Sara Bandres-Ciga1, Faraz Faghri1,2, Elisa Majounie3
1Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Medrxiv : the Preprint Server for Health Sciences
|November 21, 2023
Summary
The new Illumina NeuroBooster array (NBA) enhances genetic studies for neurological disorders, improving diversity and global research inclusivity. This cost-effective platform screens for thousands of neuro-specific variants across diverse populations.
Area of Science:
- Genetics
- Neuroscience
- Genomics
Background:
- Genetic studies for neurological disorders often lack diverse population representation.
- The Global Parkinson's Genetics Program (GP2) and Center for Alzheimer's and Related Dementias (CARD) aim to increase diversity in genetic research.
- Existing genotyping platforms have limitations in capturing population-specific genetic diversity.
Conclusions:
- The Illumina NeuroBooster array (NBA) is a powerful, cost-effective tool for advancing genetic research in neurological disorders.
- The NBA promotes inclusivity by enabling standardized genetic studies across diverse ancestral groups globally.
- This platform is expected to accelerate the discovery of genetic factors contributing to diseases like Parkinson's and Alzheimer's.
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