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Selection of experience for memory by hippocampal sharp wave ripples.

Wannan Yang1,2, Chen Sun3, Roman Huszár2

  • 1Center for Neural Science, New York University, NY, USA.

Biorxiv : the Preprint Server for Biology
|November 21, 2023
PubMed
Summary

The brain tags experiences for memory consolidation using sharp wave ripples (SPW-Rs). During sleep, SPW-Rs replay frequently reactivated awake experiences, selecting them for lasting memory.

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The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
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