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[Bone/cartilage immunomodulating hydrogels: construction strategies and applications].

Maoyuan Li1,2, Guoshuang Zheng2, Jiahui Yang2

  • 1Zhongshan Clinical College of Dalian University, Dalian Liaoning, 116001, P. R. China.

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi = Zhongguo Xiufu Chongjian Waike Zazhi = Chinese Journal of Reparative and Reconstructive Surgery
|November 21, 2023
PubMed
Summary

Bone/cartilage immunomodulating hydrogels are engineered to regulate immune responses, promoting tissue regeneration. These advanced materials show promise for treating bone and cartilage defects.

Keywords:
Bone/cartilage tissue engineeringconstruction strategyhydrogelimmunomodulation

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Area of Science:

  • Biomaterials Science
  • Immunology
  • Regenerative Medicine

Background:

  • Osteochondral defects pose significant clinical challenges.
  • Current treatments often lack efficacy in fully restoring bone and cartilage function.
  • The immune response plays a critical role in tissue healing and regeneration.

Approach:

  • Reviewed literature on immunomodulating hydrogels for bone and cartilage repair.
  • Examined immune cell response mechanisms and hydrogel construction strategies.
  • Summarized applications and future directions for these advanced biomaterials.

Key Points:

  • Immunomodulating hydrogels are designed based on immune response mechanisms.
  • These hydrogels possess biocompatibility, adjustability, and multifunctionality.
  • Tailoring hydrogel properties and loaded factors/cells creates an environment conducive to osteochondral regeneration.

Conclusions:

  • Immunomodulating hydrogels promote osteochondral repair by modulating the host immune response.
  • They exhibit broad application prospects for osteochondral defect repair.
  • Further basic and clinical research is necessary for clinical translation.