Related Experiment Video
Updated: Jul 10, 2025

Breathing-controlled Electrical Stimulation BreEStim for Management of Neuropathic Pain and Spasticity
Published on: January 10, 2013
[Research advances on neurally adjusted ventilatory assist]
Yuliang Sheng1, Wei Shao2, Yuhao Wang1
1Department of Respiratory and Critical Care Medicine, the Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang 222000, Jiangsu, China.
Neurally adjusted ventilatory assist (NAVA) uses diaphragm electrical activity (EAdi) for synchronized, patient-centered breathing support. This advanced mechanical ventilation method improves outcomes and reduces ventilator-induced lung injury risk.
Area of Science:
- Critical Care Medicine
- Respiratory Physiology
- Biomedical Engineering
Background:
- Mechanical ventilation has evolved from controlled to assisted modes.
- Conventional ventilators rely on flow sensors and pressure controllers.
- Neurally adjusted ventilatory assist (NAVA) represents a significant advancement.
Approach:
- NAVA monitors the electrical activity of the diaphragm (EAdi).
- EAdi serves as the primary signal for sensing respiratory drive and triggering support.
- This approach allows for patient-centered, synchronized ventilatory assistance.
Key Points:
- NAVA synchronizes breathing instructions with the patient's neural signals.
- It offers patient-adjusted support levels, promoting natural respiratory effort.
- NAVA effectively unloads respiratory muscles and mitigates ventilator-induced lung injury (VILI).
Conclusions:
- NAVA enhances patient-ventilator coordination and gas exchange.
- It improves the success rate of weaning patients from mechanical ventilation.
- This review provides theoretical guidance for the clinical application of NAVA.
More Related Videos
Related Concept Videos
Mechanical Ventilation III: Noninvasive Ventilation
Noninvasive Positive-Pressure Ventilation...
Ventilatory Modes
There are three ventilatory modes: full support, partial support, and spontaneous. These are described below.
Full Support Modes
Full support modes include controlled mechanical ventilation, continuous mandatory...
Mechanical Ventilation II: Invasive Ventilation
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
Mechanical Ventilation I: Indication and Settings
Assessment of Ventilation I: Respiratory Rate
A Ventilation assessment is critical for monitoring a patient's health status. Respiration, one of the most accessible vital signs, provides insights into the function of numerous body systems and can indicate serious health issues, such as brainstem injuries from head trauma.
Critical Guidelines for Assessing Ventilation:
Physiology of Respiration II: Neurogenic Control of Respiration
Central Control
The brainstem is the primary site of central control, hosting respiratory centers:

