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Adaptive pathfinding by nucleokinesis during amoeboid migration
Janina Kroll1, Robert Hauschild2, Artur Kuznetcov1
1Biomedical Center Munich (BMC), Walter Brendel Center of Experimental Medicine, Institute of Cardiovascular Physiology and Pathophysiology, University Hospital, Ludwig Maximilians University Munich, Munich, Germany.
The EMBO Journal
|November 21, 2023
Summary
Amoeboid cells navigate complex environments using nuclear repositioning (nucleokinesis). This process allows cells to adapt to competing signals, crucial for immunity and disease.
Area of Science:
- Cell Biology
- Biophysics
- Mechanobiology
Background:
- Motile cells navigate complex microenvironments with multiple guidance cues.
- Understanding how cells respond to competing signals is crucial for cell migration.
Purpose of the Study:
- To investigate the role of nuclear repositioning (nucleokinesis) in amoeboid cell pathfinding.
- To elucidate the mechanisms underlying adaptive navigation in heterogeneous environments.
Main Methods:
- Studied mammalian immune cells and Dictyostelium discoideum.
- Observed and analyzed nuclear repositioning during cell migration.
- Investigated the role of myosin-II forces in nucleokinesis.
Main Results:
- Frequent, rapid nucleokinesis is essential for amoeboid pathfinding.
- Nucleokinesis enables cells to reorient between competing cues.
- Impaired nucleokinesis leads to navigation defects and cellular arrest.
Conclusions:
- Nucleokinesis is a fundamental mechanism for amoeboid cell navigation.
- This process is vital for unicellular organisms, immunity, and disease progression involving cell migration.
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