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Adaptive pathfinding by nucleokinesis during amoeboid migration.

Janina Kroll1, Robert Hauschild2, Artur Kuznetcov1

  • 1Biomedical Center Munich (BMC), Walter Brendel Center of Experimental Medicine, Institute of Cardiovascular Physiology and Pathophysiology, University Hospital, Ludwig Maximilians University Munich, Munich, Germany.

The EMBO Journal
|November 21, 2023
PubMed
Summary
This summary is machine-generated.

Amoeboid cells navigate complex environments using nuclear repositioning (nucleokinesis). This process allows cells to adapt to competing signals, crucial for immunity and disease.

Keywords:
cell migrationcell polaritymechanochemical cuesmyosinnuclear positioning

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Area of Science:

  • Cell Biology
  • Biophysics
  • Mechanobiology

Background:

  • Motile cells navigate complex microenvironments with multiple guidance cues.
  • Understanding how cells respond to competing signals is crucial for cell migration.

Purpose of the Study:

  • To investigate the role of nuclear repositioning (nucleokinesis) in amoeboid cell pathfinding.
  • To elucidate the mechanisms underlying adaptive navigation in heterogeneous environments.

Main Methods:

  • Studied mammalian immune cells and Dictyostelium discoideum.
  • Observed and analyzed nuclear repositioning during cell migration.
  • Investigated the role of myosin-II forces in nucleokinesis.

Main Results:

  • Frequent, rapid nucleokinesis is essential for amoeboid pathfinding.
  • Nucleokinesis enables cells to reorient between competing cues.
  • Impaired nucleokinesis leads to navigation defects and cellular arrest.

Conclusions:

  • Nucleokinesis is a fundamental mechanism for amoeboid cell navigation.
  • This process is vital for unicellular organisms, immunity, and disease progression involving cell migration.