Major Adverse Cardiac and Cerebrovascular Events in Geriatric Patients with Obstructive Sleep Apnea: An Inpatient...

Area of Science:

• Geriatric Medicine
• Cardiology
• Neurology
• Sleep Medicine

Background:

• Obstructive sleep apnea (OSA) is linked to increased major cardiac and cerebrovascular events (MACCE).
• Limited data exists on the prevalence and predictors of MACCE specifically within the geriatric population with OSA (G-OSA).

Purpose of the Study:

• To determine the burden of MACCE in geriatric patients with OSA.
• To identify demographic and clinical predictors associated with MACCE in this population.

Main Methods:

• Analysis of the 2018 National Inpatient Sample database.
• Identification of geriatric OSA admissions (age ≥ 65 years).
• Comparison of demographics and comorbidities between non-MACCE and MACCE cohorts.
• Multivariate regression analysis to determine odds ratios for MACCE and in-hospital mortality.

Main Results:

• 9.9% of 1,141,120 geriatric OSA admissions experienced MACCE.
• Higher MACCE rates were observed in males, Asian/Pacific Islander/Native American races, and the lowest income quartile.
• Key predictors of MACCE included pulmonary circulation disease (OR 1.47), coagulopathy (OR 1.43), and peripheral vascular disease (OR 1.34).

Conclusions:

• Geriatric OSA patients have a substantial burden of MACCE, with specific demographic groups being more vulnerable.
• Pulmonary circulation disease, coagulopathy, and peripheral vascular disease are significant predictors of MACCE in this cohort.
• Findings support enhanced risk stratification and targeted interventions for geriatric OSA patients to mitigate MACCE risk.