Related Experiment Video

Updated: Jul 10, 2025

Quantified Assessment of Infant's Gross Motor Abilities Using a Multisensor Wearable
09:24

Quantified Assessment of Infant's Gross Motor Abilities Using a Multisensor Wearable

Published on: May 17, 2024

1.4K

Early psychomotor development and growth hormone therapy in children with Prader-Willi syndrome: a review

Yu-Yu Jin1, Fei-Hong Luo2

  • 1Department of Pediatric Endocrinology and Inherited Metabolic Diseases, Children's Hospital of Fudan University, National Children's Medical Center, 399 Wan Yuan Road, Min Hang District, Shanghai, 201102, China.

European Journal of Pediatrics
|November 21, 2023
PubMed

Insights

Early intervention is key for Prader-Willi syndrome (PWS), a genetic disorder. Early psychomotor development impacts prognosis, and timely treatments can improve cognitive and language skills, helping children with PWS catch up in motor development.

Area of Science:

  • Genetics
  • Developmental Pediatrics
  • Endocrinology

Background:

  • Prader-Willi syndrome (PWS) is a rare genetic disorder impacting chromosome 15q11-q13.
  • Children with PWS experience developmental delays, particularly in cognitive and motor skills.
  • Recombinant human growth hormone (rhGH) is the sole approved medical treatment for PWS.

Purpose of the Study:

  • To review early cognitive, language, and motor development in PWS patients.
  • To correlate genotype with phenotype in PWS.
  • To update on rhGH therapy's effects on psychomotor development, growth, and body composition in children with PWS.

Main Methods:

  • Literature review of studies on PWS development and rhGH treatment.
  • Analysis of genotype-phenotype correlations.
  • Evaluation of short- and long-term outcomes of rhGH therapy, including adverse effects.

Main Results:

  • Early psychomotor development is a strong predictor of PWS patient prognosis.
  • Early interventions significantly benefit cognitive and linguistic development in PWS.
  • rhGH therapy's impact on psychomotor development, growth, and body composition is reviewed, including potential side effects.

Conclusions:

  • Early intervention strategies are crucial for improving outcomes in PWS.
  • Understanding genotype-phenotype correlations aids in predicting developmental trajectories.
  • Comprehensive review of rhGH therapy provides insights into its benefits and risks for children with PWS.

Keywords:
Cognitive functionGrowth hormoneLanguage developmentMental and motor developmentPrader-Willi syndromePsychomotor development

More Related Videos

Enhancing the Development and Growth of Infant Cerebral Palsy Rats Using Selective Spinal Manipulations05:04

Enhancing the Development and Growth of Infant Cerebral Palsy Rats Using Selective Spinal Manipulations

Published on: February 2, 2024

583
A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy10:02

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy

Published on: November 3, 2016

24.3K

Related Concept Videos

Nature and Nurture01:10

Nature and Nurture

Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
20.5K
Signs of Puberty01:27

Signs of Puberty

Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
368
Major Hormones and Their Functions01:27

Major Hormones and Their Functions

Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
424
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
68
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.7K