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Mortality Among Persons With HIV in the United States During the COVID-19 Pandemic: A Population-Level Analysis
Alex Viguerie1, Ruiguang Song1, Karin Bosh2
1Centers for Disease Control and Prevention (CDC), National Center for HIV, Viral Hepatitis, STD, and TB Prevention (NCHHSTP), Division of HIV Prevention (DHP), Quantitative Sciences Branch (QSB), Atlanta, GA; and.
Insights
The COVID-19 pandemic did not disproportionately increase mortality for people with diagnosed HIV (PWDH) in the US. Mortality increases among PWDH were similar to or smaller than the general population.
Area of Science:
- Epidemiology
- Public Health
- Infectious Disease
Background:
- The COVID-19 pandemic's impact on mortality among people with diagnosed HIV (PWDH) in the US remains unclear.
- Understanding this impact is crucial for public health interventions and resource allocation.
Purpose of the Study:
- To analyze the effect of the COVID-19 pandemic on mortality rates among PWDH in the United States.
- To compare mortality trends in PWDH with the general population during the pandemic.
Main Methods:
- Utilized mortality and population data from 2018-2020 from the National HIV Surveillance System and public sources.
- Calculated mortality rates and excess mortality for PWDH and the general population.
- Analyzed changes in mortality risk ratios, stratified by age, race/ethnicity, and sex.
Main Results:
- Approximately 1550 excess deaths occurred among PWDH in 2020, primarily affecting Black, Hispanic/Latino individuals, and those aged 55+.
- Mortality rates increased across the general population and among PWDH in 2020 compared to 2018-2019.
- Increases in mortality among PWDH were similar to or smaller than those in the general population, decreasing the mortality risk ratio by 7.7%.
Conclusions:
- Despite increased mortality rates in 2020, PWDH did not experience a disproportionately elevated risk from the COVID-19 pandemic compared to the general population.
- Findings were consistent across age, sex, and racial/ethnic subpopulations.
- The study provides evidence against an elevated mortality risk for PWDH due to the COVID-19 pandemic.
Background:
Whether the COVID-19 pandemic has had a disproportionate impact on mortality among persons with diagnosed HIV (PWDH) in the United States is unclear. Through our macroscale analysis, we seek to better understand how the COVID-19 pandemic affected mortality among PWDH.
Methods:
We obtained mortality and population data for the years 2018-2020 from the National HIV Surveillance System for the US PWDH population and from publicly available data for the general population. We computed mortality rates and excess mortality for both the general and PWDH populations. Stratifications by age, race/ethnicity, and sex were considered. For each group, we determined whether the 2020 mortality rates and mortality risk ratio showed a statistically significant change from 2018 to 2019.
Results:
Approximately 1550 excess deaths occurred among PWDH in 2020, with Black, Hispanic/Latino, and PWDH aged 55 years and older comprising the majority of excess deaths. Mortality rates increased in 2020 from 2018-2019 across the general population in all groups. Among PWDH, mortality rates either increased or showed no statistically significant change. These increases were similar to, or smaller than, those observed in the general population, resulting in a 7.7% decrease in the mortality risk ratio between PWDH and the general population.
Conclusions:
While mortality rates among PWDH increased in 2020 relative to 2018-2019, the increases were smaller, or of similar magnitude, to those observed in the general population. We thus do not find evidence of elevated mortality risk from the COVID-19 pandemic among PWDH. These findings held across subpopulations stratified by age, sex, and racial/ethnic group.
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