[Interaction of isolated influenza virus hemagglutinin with flat lipid membranes]

The interaction of isolated influenza virus hemagglutinin with cell membranes was studied on the model of flat lipid membranes from lecithin and azolectin. Protein molecules were shown to adsorb on the membrane, and permeability of the latter increases when a certain concentration is reached. At the stages of adsorption and penetration into the lipid bilayer the hemagglutinin (HA) showed positive cooperation in interaction with the membranes. At the stage of HA adsorption on the membrane in the presence of M protein, transmembrane interaction occurs between M-protein and HA. It is concluded that molecular mechanisms participate in the HA interaction with cell membrane of the infected host cell.