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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

594
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
594
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

458
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Genomics02:02

Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

528
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
528
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

13.5K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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Human Genetics01:28

Human Genetics

586
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
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Transcending genome-wide association studies to create useful multi-omic views of glaucoma.

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Related Experiment Video

Updated: Jul 10, 2025

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
13:47

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

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Genomics enabling personalised glaucoma care.

Kelsey V Stuart1, Anthony P Khawaja2

  • 1NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK kelsey.stuart.20@ucl.ac.uk.

The British Journal of Ophthalmology
|November 21, 2023
PubMed
Summary
This summary is machine-generated.

Genomics offers a path to personalized glaucoma care, enabling targeted screening and risk prediction. This approach promises to revolutionize glaucoma detection and management for better patient outcomes.

Keywords:
EpidemiologyGeneticsGlaucomaIntraocular pressure

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Area of Science:

  • Ophthalmology
  • Genetics
  • Public Health

Background:

  • Glaucoma is a primary cause of vision loss globally.
  • Current management faces challenges despite advancements.
  • Increasing prevalence necessitates innovative, cost-effective solutions.

Purpose of the Study:

  • To explore the role of genomics in advancing glaucoma care.
  • To highlight how genetic insights can enable precision medicine for glaucoma.
  • To discuss the potential for genomics in population screening and risk stratification.

Main Methods:

  • Review of current genomic technologies and their application to glaucoma.
  • Analysis of potential for genetic testing in personalized risk prediction.
  • Discussion of implications for targeted screening and treatment strategies.

Main Results:

  • Genomics can facilitate cost-effective, targeted population screening.
  • Personalized risk prediction and treatment response can be improved through genetic profiling.
  • Advances in genetic testing support population-level genotyping.

Conclusions:

  • Genomics holds significant promise for revolutionizing glaucoma detection and management.
  • Precision medicine approaches tailored to individual genetic profiles are feasible.
  • Genomic insights are crucial for addressing the growing public health burden of glaucoma.