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[Hemodynamics and coronary dynamics under ISDN long-term therapy]
Zeitschrift Fur Kardiologie
|January 1, 1986
Summary
This study shows that sustained-release isosorbide dinitrate (ISDN) effectively improves exercise capacity and cardiac function in patients with coronary heart disease, even with long-term use.
Area of Science:
- Cardiology
- Pharmacology
Context:
- Nitrate tolerance is a persistent challenge in cardiovascular therapy.
- Isosorbide dinitrate (ISDN) is a long-established cardiovascular drug.
- Coronary heart disease (CHD) and impaired left ventricular function require effective management.
Purpose:
- To evaluate the efficacy of initial versus chronic (4-week) therapy with 120 mg sustained-release ISDN.
- To assess hemodynamic and functional improvements in patients with CHD and impaired left ventricular function.
Summary:
- Sustained-release ISDN significantly reduced pulmonary capillary wedge pressure (PCWPm) during exercise.
- Cardiac index (CI) and exercise capacity (watt x min) showed marked improvements with both initial and chronic ISDN therapy.
- ST-segment depression on ECG decreased, indicating reduced myocardial ischemia.
Impact:
- Sustained-release ISDN demonstrates sustained efficacy in improving cardiac performance and exercise tolerance in CHD patients.
- The findings suggest that tolerance to ISDN may not be a significant issue with this sustained-release formulation.
- This research supports the continued use of ISDN in managing coronary heart disease, highlighting its long-term benefits.