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Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

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Choroidal Perfusion Changes After Vitrectomy for Myopic Traction Maculopathy.

Miguel A Quiroz-Reyes¹, Erick A Quiroz-Gonzalez², Miguel A Quiroz-Gonzalez¹

¹Retina Department of Oftalmologia Integral ABC (Medical and Surgical Nonprofit Organization), National Autonomous University of Mexico, Ciudad de Mexico, Mexico.

Seminars in Ophthalmology

|November 22, 2023

Summary

The choroidal vascularity index (CVI) did not differ preoperatively in myopic traction maculopathy (MTM) but decreased post-surgery. CVI and choriocapillaris flow area (CFA) changes after MTM surgery suggest choroidal alterations, but CVI is not a reliable surgical outcome predictor.

Keywords:

Central subfield thickness choriocapillaris flow area choroidal vascularity index myopic traction maculopathy pathologic myopia

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Published on: May 26, 2023

Area of Science:

Ophthalmology
Retinal Diseases
Vascular Biology

Background:

The choroid supplies the outer retina and is affected in retinal diseases like myopic traction maculopathy (MTM).
Choroidal thickness measurement has limitations; the choroidal vascularity index (CVI) offers quantitative vascular flow data.
CVI has been studied in various diseases but not extensively characterized in MTM.

Purpose of the Study:

To investigate CVI across different MTM stages.
To assess the impact of macular surgery on choroidal perfusion markers in surgically treated MTM.
To evaluate CVI as a potential biomarker for MTM surgical outcomes.

Main Methods:

Enhanced optical coherence tomography (OCT) imaging was used for 18 healthy myopic eyes and 46 MTM eyes.
Binarized OCT images allowed calculation of CVI, luminal choroidal area (LCA), and stromal choroidal area (SCA).
Choriocapillaris flow area (CFA) and central subfield thickness (CSFT) were also measured alongside CVI at baseline and postoperatively.

Main Results:

Postoperative vision significantly improved in MTM patients (p < 0.0001).
No significant baseline differences in CVI, CFA, or CSFT were found between control and MTM groups.
Postoperatively, CVI and CFA were significantly lower in the MTM group compared to controls (p ≤ 0.0001), with no significant differences among MTM stages.

Conclusions:

Preoperative CVI did not differ between healthy myopic eyes and MTM eyes.
Postoperative CVI and CFA were significantly reduced compared to controls, indicating choroidal changes after surgery.
CVI is not a reliable biomarker for surgical outcomes in MTM due to a lack of significant correlation with visual acuity.