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Related Experiment Video

Updated: Jul 10, 2025

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
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Development and Challenges of Cyclic Peptides for Immunomodulation.

Xianqiong Jiang1, Li Gao1, Zhilong Li1

  • 1School of Pharmacy and Bioengineering, Chongqing University of Technology, 405400 Chongqing, China.

Current Protein & Peptide Science
|November 22, 2023
PubMed
Summary

Cyclic peptides offer enhanced stability and therapeutic potential for various diseases. This review highlights their role in immunomodulation and summarizes clinical applications, despite ongoing development challenges.

Keywords:
Cyclic peptidesanti-inflammatoryimmunity mechanismsimmunomodulationmultiple sclerosis.pharmacological activities

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Area of Science:

  • Medicinal Chemistry
  • Pharmacology
  • Biochemistry

Background:

  • Cyclic peptides are gaining attention in medicine due to unique advantages over linear peptides.
  • These advantages include increased stability, stronger affinity, improved selectivity, and reduced toxicity.

Purpose of the Study:

  • To review the therapeutic applications of cyclic peptides, particularly in immunomodulation.
  • To summarize cyclic peptides in clinical trials and recently approved drugs for medical applications.

Main Methods:

  • Literature review of cyclic peptides in anti-cancer, anti-inflammatory, anti-viral, multiple sclerosis, and membranous nephropathy treatments.
  • Summary of cyclic peptides in clinical trials and marketed drugs from the last five years.

Main Results:

  • Cyclic peptides demonstrate significant potential in treating various diseases via immunomodulation.
  • Several cyclic peptides are in clinical trials, and some have been approved for marketing in recent years.

Conclusions:

  • Cyclic peptides show great promise for treating diverse diseases due to their inherent advantages.
  • Challenges remain in the development process of cyclic peptides for widespread clinical use.