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The changes in cognitive function following bariatric surgery considering the function of gut microbiome
Milad Kheirvari1, Vivienne A Lacy2, Hamidreza Goudarzi3
1Microbiology Research Centre, Pasteur Institute of Iran, Tehran, Iran.
Obesity Pillars
|November 22, 2023
Summary
Bariatric surgery may reduce Alzheimer's disease risk by improving gut bacteria and neurotransmitters. This intervention benefits individuals with obesity and cognitive impairment, promoting better brain health.
Area of Science:
- Neuroscience
- Gastroenterology
- Metabolic disorders
Background:
- Obesity is linked to cognitive impairment and an increased risk of Alzheimer's disease.
- Gut microbiota plays a crucial role in the gut-brain axis and cognitive function.
- Individuals with a Body Mass Index (BMI) over 40 kg/m² face a higher risk of cognitive dysfunction.
Purpose of the Study:
- To review the association between obesity, cognitive impairment, and physiological changes post-bariatric surgery.
- To explore the mechanisms linking gut microbiota, bariatric surgery, and cognitive outcomes.
- To understand how bariatric surgery impacts Alzheimer's disease risk.
Main Methods:
- Literature review of studies on bariatric surgery, obesity, cognitive function, and gut microbiome.
- Analysis of physiological changes and their correlation with cognitive improvements.
- Examination of the role of gut microbiota in mediating the effects of bariatric surgery on cognition.
Main Results:
- Bariatric surgery leads to physiological benefits that can enhance cognitive functions, particularly in those at risk for Alzheimer's disease.
- Alterations in gut microbiome composition post-surgery contribute to improved cognitive health and reduced neuropathological damage.
- Reduced incidence of Alzheimer's disease observed in subjects who underwent bariatric surgery compared to other individuals with obesity.
Conclusions:
- A correlation exists between high BMI (over 40 kg/m²) and increased risk of cognitive dysfunction.
- Bariatric surgery may mitigate Alzheimer's disease risk by modulating neurotransmitters and improving gut bacteria profiles.
- The gut microbiome's role is critical in the beneficial cognitive effects observed after bariatric surgery.
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