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Obesity01:24

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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
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Binge eating disorder is a significant mental health condition characterized by recurrent episodes of excessive food consumption within a short period, accompanied by a perceived loss of control over eating behavior. Unlike occasional overeating, binge eating disorder is marked by distressing emotions such as guilt, shame, and anxiety following binge episodes. The disorder affects individuals across different ages and backgrounds, with profound implications for physical and psychological...
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Drug control governance involves the oversight and regulation of pharmaceuticals to ensure their safety and efficacy while preventing illegal drug use and trafficking. Regulatory bodies, including the US Food and Drug Administration (FDA) and the European Union's European Medicines Agency (EMA), play a central role in this process. These agencies evaluate the safety and efficacy of drugs before they can be marketed. They fund clinical trials and assess the benefits and risks associated with...
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Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
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Obesity pillars roundtable: Phentermine - Past, present, and future.

Harold Edward Bays1, Ethan Lazarus2, Craig Primack3

  • 1Diplomate of American Board of Obesity Medicine, Louisville Metabolic and Atherosclerosis Research Center, University of Louisville Medical School, 3288 Illinois Avenue, Louisville, KY, 40213, USA.

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Phentermine is a short-term obesity treatment. Expert opinions vary on its efficacy, cardiovascular risks, and telehealth use, highlighting the need for more data.

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Area of Science:

  • Pharmacology
  • Endocrinology
  • Cardiology

Background:

  • Phentermine is a sympathomimetic amine approved for short-term obesity treatment.
  • Contraindications include cardiovascular disease and uncontrolled hypertension.

Purpose of the Study:

  • To gather expert perspectives on phentermine's clinical use, safety, and efficacy.
  • To explore variations in phentermine prescription practices among obesity specialists.

Main Methods:

  • Roundtable discussion with three obesity specialists.
  • Questions derived from existing literature on phentermine safety and efficacy.

Main Results:

  • General agreement on core phentermine use principles, but individual variations in perceived efficacy and benefit.
  • Differing views on cardiovascular risk, necessity of screening ECGs, and telehealth's role in phentermine management.

Conclusions:

  • Lack of long-term, prospective data complicates universal guidance for phentermine.
  • Varied governmental restrictions and clinical experiences necessitate reliance on best available evidence and collective insights.