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Rapid Intrafibrillar Mineralization Strategy Enhances Adhesive-Dentin Interface.

X Gao1, Z Wang2, H Yang1

  • 1State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, Hubei, China.

Journal of Dental Research
|November 22, 2023
PubMed
Summary

A new prebonding mineralization strategy using polyacrylic acid-stabilized amorphous calcium fluoride (PAA-ACF) rapidly strengthens dentin collagen. This approach enhances bonding durability and inhibits degradation, offering a promising solution for dental restorations.

Keywords:
biomaterials(s)bondingcollagen(s)fluoride(s)mechanical propertiesrestorative materials

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Area of Science:

  • Biomaterials Science
  • Dental Materials Science
  • Nanotechnology

Background:

  • Biomimetic mineralization of dentin collagen is key for durable dentin bonding.
  • Traditional methods face challenges like long treatment times and limited intrafibrillar mineralization.

Purpose of the Study:

  • To develop a rapid, prebonding intrafibrillar mineralization strategy for dentin.
  • To evaluate the efficacy of polyacrylic acid-stabilized amorphous calcium fluoride (PAA-ACF) in enhancing dentin bonding.

Main Methods:

  • Utilized polyacrylic acid-stabilized amorphous calcium fluoride (PAA-ACF) for rapid mineralization.
  • Employed transmission electron microscopy, scanning electron microscopy, and atomic force microscopy to analyze mineralization.
  • Assessed mechanical properties and bonding strength of treated dentin samples.

Main Results:

  • PAA-ACF induced rapid intrafibrillar mineralization of collagen within 1-10 minutes.
  • Strengthened mechanical properties of demineralized dentin in a clinically relevant timeframe.
  • Achieved superior bonding strength compared to control groups and inhibited collagen degradation.

Conclusions:

  • Proposed the concept of "prebonding rapid intrafibrillar mineralization" using PAA-ACF.
  • Demonstrated PAA-ACF as a multifunctional primer for improved dentin bonding durability.
  • Highlighted the potential of this strategy to extend the lifespan of adhesive dental restorations.