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Multichannel Multijunction Droplet Microfluidic Device to Synthesize Hydrogel Microcapsules with Different Core-Shell

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  • 1Center for Modern Physics Technology, School of Mathematics and Physics, University of Science and Technology Beijing, Beijing 100083, China.

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We developed a novel microfluidic technique to create versatile core-shell hydrogel microcapsules. These adaptable microcapsules are promising for drug delivery and screening applications.

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Area of Science:

  • Biomaterials Science
  • Microfluidics
  • Drug Delivery Systems

Background:

  • Core-shell hydrogel microcapsules offer significant potential in medicine, pharmaceuticals, and cosmetics.
  • Current synthesis methods are often complex and costly, hindering practical applications.

Purpose of the Study:

  • To design and fabricate microfluidic devices for efficient synthesis of core-shell hydrogel microcapsules.
  • To explore different cross-linking methods for creating diverse microcapsule structures.
  • To demonstrate the stimuli-responsive and controlled release capabilities of the synthesized microcapsules.

Main Methods:

  • Utilized soft lithography to create multichannel, multifunctional droplet microfluidic devices.
  • Employed ultraviolet (UV) cross-linking to synthesize gelatin methacryloyl (GelMA) core/polyacrylamide (PAM) shell microcapsules.
  • Implemented interfacial polymerization for GelMA core/alginate-polyethylenimine (PEI) shell microcapsules, controlling dimensions via device carving.

Main Results:

  • Successfully synthesized various core-shell hydrogel microcapsules with tunable sizes.
  • Demonstrated stimuli-responsiveness and controlled release properties.
  • Developed a novel, adaptable technique for microcapsule fabrication.

Conclusions:

  • The developed microfluidic approach enables effective synthesis of diverse core-shell hydrogel microcapsules.
  • These microcapsules facilitate coassembly of cells and drugs for synergistic therapies.
  • The adaptable microcapsules show promise for multi-drug/cell delivery and high-throughput drug screening.