Lead-oriented synthesis of epigenetic relevant scaffolds
Timothé Maujean1, Prakash Kannaboina1, Adam I Green1
1Department of Biochemistry and Biophysics, Department of Cancer Biology and Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, PA 19104, USA. George.Burslem@Pennmedicine.upenn.edu.
Chemical Communications (Cambridge, England)
|November 22, 2023
Abstract:
A simple and rational method to rank lead-likeness of molecules using continuous evaluation functions was hereby developed. This strategy proved to be competitive against known methods and finally helped in driving synthetic efforts towards candidates of interest for epigenetic applications against HDAC6, BRD4 and EZH2.
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