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Updated: Jul 10, 2025

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins
Published on: June 11, 2015
Diversity and conservation of the genome architecture of phages infecting the Alphaproteobacteria
Jonathan R Hyde1, Thomas Armond1, Jacob A Herring1
1Department of Microbiology and Molecular Biology, Brigham Young University , Provo, Utah, USA.
Importance:
This study reports the results of the largest analysis of genome sequences from phages that infect the Alphaproteobacteria class of bacterial hosts. We analyzed over 100 whole genome sequences of phages to construct dotplots, categorize them into genetically distinct clusters, generate a bootstrapped phylogenetic tree, compute protein orthologs, and predict packaging strategies. We determined that the phage sequences primarily cluster by the bacterial host family, phage morphotype, and genome size. We expect that the findings reported in this seminal study will facilitate future analyses that will improve our knowledge of the phages that infect these hosts.
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