Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Necrosis01:16

Necrosis

4.5K
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
4.5K
Teeth01:15

Teeth

439
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
439

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antibacterial, In Vitro Anti-Inflammatory and Anti-Acne Activities of <i>Patchouli</i> Essential Oil.

Pharmaceuticals (Basel, Switzerland)·2026
Same author

Single-cell analyses identify the ginseng embryonic protoderm as a native compartment for high-efficiency ginsenoside production.

Nature communications·2026
Same author

[Analysis of complicating factors in endodontic microsurgery].

Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology·2026
Same author

Developing WNT-derived bone anabolic peptides for skeletal aging and fracture by reconstructing thumb and index domains of WNT7B.

Nature biomedical engineering·2026
Same author

Impact of aerosol acidity on the heterogeneous chemistry of halogenated phenols.

Environmental pollution (Barking, Essex : 1987)·2026
Same author

Network toxicology and molecular docking identify BRCA1 as a functional target of the dietary carcinogen PhIP in colorectal cancer.

Discover oncology·2026

Related Experiment Video

Updated: Jul 10, 2025

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
04:01

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Published on: March 15, 2024

1.0K

Overburdened ferroptotic stress impairs tooth morphogenesis.

Haisheng Wang1, Xiaofeng Wang1,2, Liuyan Huang1,2

  • 1State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Elife
|November 22, 2023
PubMed
Summary

Ferroptosis, a cell death pathway, plays a role in tooth development. While ferroptotic stress increases, the enzyme Gpx4 balances it, preventing developmental defects unless stress is excessive.

Keywords:
cell deathdevelopmental biologyferroptosismousetooth development

More Related Videos

Studying Orthodontic Tooth Movement in Mice
07:17

Studying Orthodontic Tooth Movement in Mice

Published on: August 2, 2024

742
Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy
11:02

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy

Published on: April 13, 2022

3.4K

Related Experiment Videos

Last Updated: Jul 10, 2025

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
04:01

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Published on: March 15, 2024

1.0K
Studying Orthodontic Tooth Movement in Mice
07:17

Studying Orthodontic Tooth Movement in Mice

Published on: August 2, 2024

742
Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy
11:02

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy

Published on: April 13, 2022

3.4K

Area of Science:

  • Cell Biology
  • Developmental Biology
  • Biochemistry

Background:

  • Regulated cell death, particularly non-apoptotic forms like ferroptosis, is crucial in organ development.
  • Ferroptosis, characterized by iron-dependent lipid peroxidation, is regulated by a balance between ferroptotic stress and anti-lipid peroxidation systems.
  • Lipid and iron metabolism, central to ferroptosis, are also vital for organogenesis.

Purpose of the Study:

  • To investigate the role and impact of ferroptosis in organogenesis using an ex vivo tooth germ culture model.
  • To examine the presence and effects of ferroptotic stress during tooth development.

Main Methods:

  • Utilized an ex vivo tooth germ culture model.
  • Assessed ferroptotic stress levels and the expression of glutathione peroxidase 4 (Gpx4) during tooth development.
  • Inhibited ferroptosis using erastin to observe effects on tooth morphogenesis.

Main Results:

  • Ferroptotic stress and Gpx4 expression increased concurrently during tooth development.
  • Inhibiting ferroptosis partially rescued erastin-induced defects in tooth morphogenesis.
  • Excessive ferroptotic stress, induced by erastin, significantly suppressed tooth morphogenesis.

Conclusions:

  • Ferroptotic stress is present during tooth organogenesis but is effectively managed by increased Gpx4 expression.
  • While controlled ferroptosis may be integral to development, excessive ferroptotic stress impairs tooth morphogenesis.