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Peripheral arterial disease--natural outcome.

R Lassila, M Lepäntalo, O Lindfors

    Acta Medica Scandinavica
    |January 1, 1986
    PubMed
    Summary

    Peripheral arterial disease significantly impacts survival, with advanced lower limb ischemia indicating a higher risk of fatal cardiovascular events in men. This study highlights the disease

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    Area of Science:

    • Cardiovascular Medicine
    • Vascular Surgery
    • Epidemiology

    Background:

    • Peripheral arterial disease (PAD) affects a significant patient population.
    • Understanding the natural history and prognostic factors of PAD is crucial for patient management.

    Purpose of the Study:

    • To assess the long-term natural history of peripheral arterial disease.
    • To identify factors influencing outcomes in patients with PAD.
    • To evaluate the prognostic significance of disease severity in PAD.

    Main Methods:

    • A prospective follow-up study of 312 patients with peripheral arterial disease.
    • Long-term follow-up (8.75 to 11.75 years) to record mortality and causes of death.
    • Analysis of risk factors including demographics, comorbidities, and disease severity.

    Main Results:

    • 188 (69%) of 312 patients died during follow-up, with 68% of deaths due to cardiovascular causes.
    • 10-year relative survival rates were 0.61 for males and 0.48 for females.
    • Advanced lower limb ischemia, independent of diabetes, was a significant predictor of increased mortality in men, indicating broader arterial involvement.

    Conclusions:

    • Peripheral arterial disease is associated with substantial long-term mortality, primarily from cardiovascular events.
    • Disease severity, particularly advanced lower limb ischemia, is a critical independent risk factor for fatal outcomes in men with PAD.
    • Advanced ischemia suggests systemic arterial disease and predicts cardiovascular events, necessitating aggressive management strategies.

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